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    帕金森病源自腸道?

    2019-06-28 06:17:12 環球時報

    美國研究團隊近日通過實驗證明了此前一項理論猜測:帕金森病可能起源于腸道,通過神經傳入大腦。

    據英國《衛報》26日報道,帕金森病和腦細胞死亡密切相關,而腦細胞死亡的誘因很可能是α-突觸核蛋白的“錯誤折疊”。約翰·霍普金斯大學的科學家將人工錯誤折疊的α-突觸核蛋白注射至小鼠的腸道,然后進行10個月的追蹤。研究人員發現,α-突觸核蛋白先是聚集在連接腸道的迷走神經,最終擴散到整個大腦。鼠腦產生多巴胺的神經元也明顯減少,因而小鼠表現出帕金森病的癥狀。研究人員稱,這項發現有助于揭示帕金森病發病進程,為早期篩查和預防提供參考。▲ (馮國川)

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